Causes of mitochondrial dysfunctions on molecular level and search for methods of their elimination

Place of work — Mitochondrial
Research Group, Institute
of Neuroscience, University
of Newcastle upon
Tyne, UK
Contacts — Framlington Place
Newcastle upon Tyne
NE2
4HH, England
+44 (191) 222–8028
R. N. Lightowlers@ncl.ac.uk http://www.ncl.ac.uk/neuro-
science/home.php
Publications — Bridging PNAs can bind preferentially to a deleted
mitochondrial DNA template but replica-
tion by mitochondrial DNA polymerase gamma in vitro is
not impaired. McGregor A, Smith
PM, Ross GF, Taylor RW, Turnbull DM, Lightowlers RN. Biochim
Biophys Acta. 2003 Oct 1;1629(1–3):73–83.
Peptide nucleic
acid delivery to human mitochondria. Chinnery PF, Taylor RW, Diekert K, Lill
R, Turnbull DM, Lightowlers RN. Gene Ther. 2000
May;7(9):813.
Progress and prospects: Gene therapy for mitochondrial
DNA disease. Kyriakouli D; Boesch P;
Taylor R; Lightowlers R. Gene Therapy. 2008, 15(14),
1017–1023.