Epigenetics and DNA methylation in normal, aging and tumor cells

Place of work — Anderson
Cancer Center, University
of Texas, USA
Contacts — 1515 Holcombe Blvd
Houston, TX 77030
(713) 745–2260
jpissa@mdanderson.org
Publications — Methylation of the oestrogen receptor CpG island links
ageing and neoplasia in human colon.
Jean-Pierre J. Issa, Yvonne L. Ottaviano, Paul Celano,
Stanley R. Hamilton, Nancy E. Da- vidson & Stephen B. Baylin. Nat Genet. 1994 Aug;7(4):536–40.
HLTF gene silencing in human colon cancer. Moinova HR,
Chen WD, Shen L, Smiraglia D,
Olechnowicz J,
Ravi L, Kasturi L, Myeroff L, Plass C, Parsons R, Minna J, Willson JK, Green
SB, Issa JP, Markowitz SD. Proc Natl Acad Sci U S A. 2002

CpG island methylator phenotypes in aging and cancer.
Toyota M, Issa JP. Semin Cancer Biol. 1999