Functions of transcription factors (Hsf) and heat shock proteins (Hsp)

Place of work — Medical
College of Georgia, USA
Contacts — 1410, Laney Walker Blvd, CN 3153 — 27A Augusta, GA 30912, USA (706) 721–8759 nmivechi@mail.mcg.edu
Publications — Heat shock factor 1 deficiency via its downstream target gene alphaB-crystallin (Hspb5) impairs p53 degradation. Jin X, Moskophidis D, Hu Y, Phillips A, Mivechi NF. J Cell Biochem. 2009 Jun 1;107(3):504–15.
Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice. Homma S, Jin X, Wang G, Tu N, Min J, Yanasak N, Mivechi NF. J Neurosci. 2007 Jul 25;27(30):7974–86.
Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regulation for stress-inducible Hsp molecular chaperones. Zhang Y, Huang L, Zhang J, Moskophidis D, Mivechi NF. J Cell Biochem. 2002;86(2):376–93.