Mitochondria biogenesis, consequences of mutations in mitochondrial DNA for human health

Place of work — Thomas
Jefferson University, USA
Contacts — 233 South 10th Street, 208
BLSB
Philadelphia,
Pennsylvania
19107
(215) 503–4845
Michael. King@jefferson.edu
Publications — Recognition of human mitochondrial tRNALeu(UUR) by its
cognate leucyl-tRNA synthetase.
Sohm, B., Sissler, M. Park, H., King, M. P., and
Florentz, C. Journal of Molecular Biology. 2004; 339, 17–29.
Lysyl-tRNA synthetase is a target for mutant SOD1
toxicity in mitochondria. Kawamata, H.,
Magrane, J., Kunst, C., King, M. P., and Manfredi, G.
Journal of Biological Chemistry. 2008; 283, 28321–28328.
Over-expressed mitochondrial leucyl-tRNA synthetase
suppresses the A3243G mutation in the
mitochondrial tRNALeu(UUR) gene. Park, H., Davidson, E.,
and King, M. P. RNA. 2008; 14,
2407–2416.