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Molecular mechanisms of stem cell aging Changes of telomeres in different physiological conditions

Place of work — Department of
Molecular, University of
Ulm, Germany
Contacts — University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany +49 (0)731/50–10 Lenhard. Rudolph@uni-ulm.de
Publications — p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B, Schirmacher P, Kestler H, Danenberg E, Barker N, Clevers H, Speicher MR, Rudolph KL. Nat Genet 2009;41:1138–43
Telomere dysfunction and DNA damage checkpoints in diseases and cancer of the gastrointestinal tract. Rudolph KL, Hartmann D, Opitz OG. Gastroenterology 2009;137:754- 62.