Problems associated with neurodegenerative diseases including age-related conditions

Place of work — Department
of Degenerative Neurological
Diseases, National
Institute of Neuroscience,
National Center of Neurology
and Psychiatry, Japan
Contacts — 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187, Japan
+81 (42) 341–2712 wada@ncnp.go.jp
http://www.ncnp.go.jp/nin/
guide/r4/index_e.html
Publications — Aberrant molecular properties shared by familial
Parkinson’s disease-associated mutant UCH-
L1 and carbonyl-modified UCH-L1. Kabuta T, Setsuie R,
Mitsui T, Kinugawa A, Sakurai M, Aoki S, Uchida K, Wada K. Hum Mol Genet. 2008
May 15;17(10):1482–96.
Insights into links between familial and sporadic
Parkinson’s disease: Physical relationship be-
tween UCH-L1 variants and chaperone-mediated autophagy.
Kabuta T, Wada K. Autophagy. 2008 Aug
16;4(6):827–9.
Aberrant Interaction between Parkinson Disease-associated
Mutant UCH-L1 and the Lysosom-
al Receptor for Chaperone-mediated Autophagy. Tomohiro
Kabuta, Akiko Furuta, Shunsuke Aoki, Koh Furuta and Keiji Wada. J Biol Chem.
2008 Aug 29; 283(35):23731–8.