Role of histone deacetylase Sir2 in aging and longevity

Place of work — Department of Biology,
Massachusetts Institute of
Technology, USA
Contacts — 77 Massachusetts Avenue,
68-280Cambridge, MA 02139
USA
(617) 258–7360 leng@mit.edu
http://web.mit.edu/biology/
guarente/
Publications — Mutation in the silencing gene SIR4 can delay aging in
Saccharomyces cerevisiae. Kennedy,
B., Austriaco, N., Zhang, J., and Guarente, L. Cell,
1995. 80, 485–496.
Link between aging and the nucleolus. Guarente, L. Genes
and Devel. 1997. 11, 2449–2555. Genetic pathways that regulate aging in model
organisms. Guarente, L. and Kenyon, C. Nature, 2000, 408, 255–262.
SIR2 and aging-the exception that proves the rule.
Guarente, L. Trends Gen. 2001, 17, 393-
393.