«Just like it took a while to crack the genetic code, we’re finally starting to crack the immune code, and we’re shifting away from the simplistic idea that there is only one type of immune system," says lead author Adrian Liston, head of the
The exception is when a person is elderly. Researchers haven’t determined exactly why age plays a major role in making our individual immune systems more unique, but they have shown that aging changes how our immune system responds to threats. As we get older, an organ called the thymus gradually stops producing T cells, which are made to help to fight off infection. Without new T cells, older people are more likely to get sick and less likely to respond to vaccines.
Beyond T cells, ageing also seems to broadly change the way our immune systems react.
«A lot of diseases that we associated with aging have an inflammatory component, which suggests there is likely immune involvement," says Michelle Linterman, a researcher at the Babraham Institute and
Differences can be overcome, however; studies of people living together have shown that air quality, food, stress levels, sleep patterns, and lifestyle choices had a strong combined effect on our immune responses. For example, couples who cohabitate have more similar immune systems compared to the general public.
Liston and his collaborators, Linterman and Edward Carr of the Babraham Institute, would next like to explore how changing our environment could purposefully shape our immune system and potentially affect our health. «In order to tinker with the immune code, we first need to really understand the influences that shape the immune system," says Liston. «That’s why it’s actually great that environment is more important than genetics, because we can play with environment.»