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Scientists create molecular tool to remove toxic protein from neuronal models of dementia

Harnessing a probe used to image the brain in diagnosing Alzheimer’s disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital (MGH) have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.  
dementia
New DNA “shredder” technique goes beyond CRISPR’s scissors

CRISPR Tool borrowed from bacteria successfully seeks out, cuts and destroys long stretches of human cells’ DNA, opening doors to new uses in research and treatment
DNA research
Autism symptoms reduced nearly 50% two years after fecal transplant

According to the Centers for Disease Control and Prevention, about one in every 59 children in the U.S. is diagnosed with autism, up from one in every 150 in 2000.

research
New study shows effects on offspring of epigenetic inheritance via sperm

In experiments with worms, researchers showed that epigenetic marks on sperm chromosomes affect gene expression and development in offspring
research
Blocking protein’s activity restores cognition in old mice

Brain cells called microglia serve as the brain’s garbage crew, scarfing up bits of cellular debris. But their underperformance in aging brains contributes to neurodegeneration. Now, a possible workaround?
research
Study: Therapy Completely Clears HPV in One-Third of Cervical Precancers

Clinical trial shows promise of immune treatment against HPV infections that lead to cancer
cancer
New Evidence Links Lifespan Extension to Metabolic Regulation of Immune System

Joslin researchers show that caloric restriction lowers levels of innate immunity and inflammation, leading to increased longevity.
research
Do ‘depression genes’ exist? It’s not so simple, new study concludes

Over the past quarter-century, researchers have published hundreds of studies suggesting a small set of particular genes or gene-variants plays a substantial role in boosting susceptibility to depression. Such papers fueled hopes that clinicians could soon use genetic testing to simply identify those at risk, and drug companies could develop medications to counteract a few genetically driven culprits.
research genetics
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