SARS-CoV-2 is critically dependent on a special mechanism for the production of its proteins. A collaborative team led by a research group at ETH Zurich obtained molecular insights into this process and demonstrated that it can be inhibited by chemical compounds, thereby significantly reducing viral replication in infected cells.
The SARS-CoV-2 virus that is causing the COVID-19 pandemic is just one of many different viruses in the coronavirus family. Many of these are circulating in populations of animals like bats and have the potential to "jump" into the human population, just as SARS-CoV-2 did. Researchers in the laboratory of Pamela Björkman, the David Baltimore Professor of Biology and Bioengineering, are working on developing vaccines for a wide range of related coronaviruses, with the aim of preventing future pandemics.