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Infectious diseases

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Viral proteins as modifiers of the cell immune response

Workers of prof. A. Badley’s laboratory study how viral proteins can modify the cell immune response, and how we can operate cell apoptosis in order to treat human diseases. A. Badley’s laboratory studied the process of neutrophil apoptosis (neutrophils are the phagocytes produced in the bone marrow). After neutrophils get into the excitation focus, they quickly become senescent. Then neutrophils come back into the marrow bone and undergo apoptosis. Return of the senescent neutrophils into the marrow bone is controlled by the stromal cell-derived factor 1 (SDF-1) which interacts with CXCR4 — the molecule senescent neutrophils express. If senescent neutrophils do not undergo apoptosis by any reason, they can cause various autoimmune diseases. It is revealed that recombinant TRAIL induced apoptosis of the senescent neutrophils. Scientists conclude that recombinant TRAIL can theoretically be used for selective elimination of the senescent neutrophils.