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Stem cells

Database
Hematopoietic stem cells

Hematopoietic stem cells usually divide several times in an adult organism. It is still unclear which factors determine the number of stem cell divisions during the lifetime. Scientists analyzed the process of stem cell self-renewal and found out that stem cells isolated from three-week-old or younger newborns had definite advantage over the cells isolated from the adult human organism. After three weeks, embryonal stem cells lose their ability to divide well and generate new cells which will differentiate into specialized tissue cells afterwards. Moreover, scientists created time scale of age-related stem cells behavior. It will become the basis for further investigations aimed at finding the initial cause of the age-related restriction in the number of stem cell divisions. Those results are of considerable value for clinical therapy — cells from three-week-old or younger newborns are the most appropriate for transplantation into adult organism.