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The best mode of the day

Database
Optimal day regimen

Authors:

O. J. Malm, v. N. Anisimov, v. M. Dilman.

History:

In 1959, it was established for the first time, that if we remove epiphysis in young rats, their life span shortens substantially compared to the control group. Data obtained were confirmed by other scientists. Later, it was shown that peptide extract of epiphysis named epytalaminum restore regular estrous cycles and sensitivity of hypothalamic sexual centers to oestrogens in mice — the mechanism that is believed to play a key role in age-related disabling of reproductive function.

Example:

Natural biological rhythms help an organism adapt to changeable environment. When those biorhythms are upset, the ability of an organism to resist unfavorable external forces decreases.

pineal body is the main pace maker in human organism. That organ produces melatonin that depress free radical processes in an organism, thereby delaying aging.

Description:

More and more information accumulates about the role of the pineal body as the main pace maker of functions of an organism. Light depresses production and secretion of melatonin, so the highest level of melatonin in the pineal body and blood is observed at night, while the lowest level — in the morning and in the daytime. When an organism ages, epiphysial function decline, so disorders of the rhythm of melatonin secretion appear and the level of melatonin secretion decreases.

Mechanisms of geroprotector effect of melatonin and epytalaminum are not fully known. The ability of those substances to depress free radical processes in an organism could be important. Melatonin, as well as epitalaminum stimulate cells of the immune system and slow aging of the immune system down; they also normalize a number of age-related disorders of lipid and carbohydrate metabolism, prolong cyclic ovarian activity in mice, restore reproductive functions in old animals and show clear anticarcinogenic effect.

Additions and Criticism:

In experiments on mice, scientists found out that geroprotector effect of melatonin was not the same in all the cases and sometimes there was no effect at all. Moreover, it was established that melatonin given to experimental animals for a long period could increase the rate of neoplasms development.


Publications:

  • Anisimov, Vladimir N., et al. «Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice." Experimental gerontology38.4 (2003): 449–461.
  • Anisimov, Vladimir N., et al. «Melatonin as antioxidant, geroprotector and anticarcinogen." Biochimica et Biophysica Acta (BBA)-Bioenergetics 1757.5 (2006): 573–589.
  • Hardeland, Rüdiger. «Melatonin and the theories of aging: a critical appraisal of melatonin’s role in antiaging mechanisms." Journal of pineal research 55.4 (2013): 325–356.
  • Malm, Ole J., Odvar E. Skaug, and Per Lingjærde. «The effect of pinealectomy on bodily growth, survival rate and P32 uptake in the rat." Acta endocrinologica 30.1 (1959): 22–28.